Hello Vivek, Thank you for your post. What is the connection status of the electrode inputs when you remove RLD? Are they connected to something, or to each other? What do the LOFF_STAT bits read in the STATUS word? The RLD amplifier is needed to maintain a mid-supply common-mode voltage at the electrode inputs. When this connection is removed, the common-mode voltage will shift away from mid-supply due to the imbalance of the lead-off current. Currently, you have one positive input selected and two negative inputs selected. This may affect the reported lead-off status for the other inputs, depending on the comparator threshold you have configured. In addition, the output of the PGA may saturate if the voltage at the input becomes large. Currently, you are using a gain of 8 V/V. If you can download TINA-TI spice simulator, try modeling your configuration and see how the voltage at each channel input / output is affected. (Please visit the site to view this file) Best Regards,
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