Hi Alex, I was using 500mV vpp square wave as test input signal and set the gain=1. I soldered another board and using ADS1291 instead of ADS1292 , and that works. I could see the external test signal or my ecg wave. Then I soldered another board with ADS1292 , everything worked. The older ADS1292 board may have broke some part. Thank you for your support Best Regards, Zhixia
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