Hi Paul, Welcome to our e2e Forum! We have had other customers use the AMC1304 in similar applications, so the quick answer to both of your questions is 'yes'. Regarding the input common mode voltage, take a look at the simplified schematic on page 1 of the AMC1304M05-Q1 datasheet, you may notice that the high side LDOIN voltage is taken from a floating supply which is referenced back to the shunt and AGND of the modulator.
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