Hello Manisha, I can't find R15, R16 and C12 on the schematic since it is blurry. When you say offset do you mean that the voltage level is changing or that the measurement stops like in the second picture? If you mean that the voltage level is changing: Do you have waveform captures showing the issue? What is the magnitude of the offset? Is the simulator GND and the ADS1298 AVSS tied together? Is there noise or an offset on AVSS? If you mean that the measurement stops like in the second picture (between the red and green waveforms): What is the communication to the device during this time? Is something resetting the device or stopping the measurement in your code?
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